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Thursday 5 April 2012
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Ancestrome: Integrative phylogenetic approaches for reconstructing ancestral "-omes"

Ancestrome is a research project that aims to study genome organization and functioning of extant living organisms to build integrative models to reconstruct evolutionary intermediates together with the evolutionary processes that have generated them.

It is funded by the ANR agency on the Bioinformatics Investissement d’avenir call.

A critical step in the development of methods to reconstruct the evolution of genomes is the modeling of the processes that relate gene phylogenies to species phylogenies. We have developed methods for integrating events of gene duplication, gene loss and lateral gene transfer in the simultaneous reconstruction of species and gene histories. These methods yield much better estimates of the gene content of ancestral genome, and hence open the door to accurate reconstructions of ancestral species characteristics. This includes cellular and genome organizations, or metabolic capabilities as deduced from genome content, but also virtually any internal or external factors that have left a trace in the genomic record, such as the environment to which the species has adapted, its resources, parasites or demography.


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